Saracens will play four-time Heineken Cup winners Toulouse at Wembley on Friday, October 18.
The headline clash in Pool Three kicks off at 7.45pm and is the second round of fixtures after the Men in Black start out away to Connacht Rugby.
Sarries will play their other two home matches against Zebre and Connacht at Allianz Park with rounds five and six yet to be confirmed.
Heineken Cup fixtures:
Round 1
October 11, 8pm: Connacht Rugby v Saracens
Round 2
October 18, 7.45pm: Saracens v Toulouse
Round 3
December 7, 2.35pm: Zebre v Saracens
Round 4
December 14, 3pm: Saracens v Zebre
Round 5
January 10/11/12: Toulouse v Saracens
Round 6
January 17/18/19: Saracens v Connacht Rugby
Knockout stages
April 4/5/6: Quarter-Finals
April 26/27: Semi-Finals
May 24: Final
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