Drivers are being warned of traffic disruption with a road set to be closed for around three months.
Hendon Wood Lane is to shut from March 7 as Affinity Water embarks on a programme to replace water mains in the area.
The water supplier says the entire road near Arkley will be closed between the junctions of Barnet Road and Highwood Hill until mid-June.
Residents and business will still be able to access Hendon Wood Lane during the closure but from Highwood Hill only.
Affinity Water says the closure is required to improve water pipes in the area with water mains being replaced in Hendon Wood Lane, Highwood Hill, and Totteridge Common.
The company says the new pipes are "essential" to help reduce disruption from leaks and bursts, as well as continue to provide a "reliable, high quality" supply of water.
The work has been agreed with Barnet Council and the Greater London Authority, with Cadent Gas and Openreach also carrying out work in the area at the same time to reduce the period of disruption in Hendon Wood Lane by seven weeks, according to Affinity Water.
Hendon Wood Lane is a popular route for drivers, particularly during rush hour, as motorists avoid the A1 between Stirling Corner and Apex Corner.
Affinity Water says diversion signs will be in place for drivers.
A statement on its website says: "From March 7 until mid-June, there'll be a full road closure on Hendon Wood Lane with a traffic diversion in place for the duration of the works.
"This is approved by the Highways Authority and is the safest route for all vehicle types. It's likely that there'll be some traffic disruption at peak times, and you may need to allow more time for your journeys."
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